Ctrp drug sensitivity
WebThe Cancer Therapeutics Response Portal (CTRP) bridges genetic, genealogical, and other cellular characteristics of cancer cell lines with small-molecule sensitivity to support future patient-matched drug discovery based on predictive biomarkers. 36 The Genomics of Drug Sensitivity in Cancer (GDSC) database characterizes 1,000 human cancer cell ... http://www.ilincs.org/help/signatureLibraries/Cancer-Therapeutics-Response-Signatures
Ctrp drug sensitivity
Did you know?
WebSep 25, 2024 · For the ‘ground truth’ model (predicting drug sensitivity in NCI60 from drug sensitivity in CTRP for shared cell lines and compounds), the dose–response AUC values from the CTRP screen were used. Cell viability assay PC3 and VCaP cell lines were purchased from ATCC. WebMay 31, 2024 · EDDY has been used in conjunction with the Cancer Therapeutics Response Portal (CTRP), a dataset with drug-response measurements for more than …
WebJan 31, 2024 · Several potential drugs, such as lapatinib, that may target TRPV channel-related genes were identified by mining the genomics of drug sensitivity. Conclusion: This study revealed the genomic changes and clinical characteristics of TRPV channel-related regulatory factors in 33 types of tumors. WebMay 31, 2024 · EDDY has been used in conjunction with the Cancer Therapeutics Response Portal (CTRP), a dataset with drug-response measurements for more than 400 small molecules, and RNAseq data of cell lines in the Cancer Cell Line Encyclopedia (CCLE) to find potential drug-mediator pairs.
WebJun 24, 2024 · The CTRP and GDSC contained data on cytarabine activity. In contrast to AML cells, however, there was no difference in the cytarabine sensitivity between B-ALL and T-ALL cell lines and no... WebSep 2, 2024 · RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma RAB6B is a potential prognostic marker and correlated with the remolding of tumor immune microenvironment in hepatocellular carcinoma eCollection 2024. Authors
WebMar 22, 2024 · Finally, P4HA3-related drugs were searched in CellMiner, Genomics of Drug Sensitivity in Cancer (GDSC), and Cancer Therapeutics Response Portal (CTRP) databases. Results: P4HA3 is significantly overexpressed in most cancers and is associated with poor prognosis.
WebApr 8, 2024 · “Sensitive cell-lines” are defined by fitting raw CTRP AUC data to a bimodal normal mixture model and establishing a threshold for sensitivity at a p-value of 0.5 with … greene county clerk office greeneville tnWebJan 17, 2024 · To provide a more rigorous assessment of model generalizability between different studies, we use machine learning to analyze five publicly available cell line-based data sets: National Cancer Institute 60, ancer Therapeutics Response Portal (CTRP), Genomics of Drug Sensitivity in Cancer, Cancer Cell Line Encyclopedia and Genentech … greene county clerk officeWebDec 16, 2024 · In this study, we have considered two expression signature collections: the PS C captures the transcriptional changes induced by a drug; while the SS C captures the sensitivity to the drug effect. In both cases, these expression signatures are obtained from a differential expression analysis, although using different designs. greene county clerk tom barrWebMar 16, 2024 · The CTRP is a living resource that will grow over time. We recently completed a second phase of new small-molecule sensitivity data collection. This phase … greene county clerk onlineWebThe Genomics of Drug Sensitivity in Cancer Project is a collaboration between the Cancer Genome Project at the Wellcome Sanger Institute (UK) and the Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center (USA). This work is … greene county clerk online recordsWebloadNCI60drugSensitivity: Load CTRP data matchStatsWithDrugSetsID: Match identifiers between data and drug sets parseCMapID: Parse CMap identifier … greene county clerk of the courtWebSep 21, 2016 · Additionally, a more recent study, the Cancer Therapeutics Response Portal (CTRP) performed drug sensitivity screening of 481 drugs on the CCLE cell lines [9, … greene county clerk\u0027s office bloomfield in