Cyp3a7 gene
WebPharos : Target Details - CYP3A7 Jump to section: close Descriptive Data Protein Summary Protein Classes IDG Development Level Summary Expression Data Protein Sequence and Structure Related Tools Behavioral Data Approved Drugs Active Ligands Protein-Protein Interactions Nearest Tclin Targets Pathways Predicted Viral Interactions Phenotypic Data WebPROTEIN FUNCTION. Gene summary (Entrez)i. Useful information about the gene from Entrez. This locus represents readthrough transcription between the neighboring CYP3A7 (cytochrome P450, family 3, subfamily A, polypeptide 7) and CYP3A51P (cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene) genes, which are members of the …
Cyp3a7 gene
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WebThe CYP3A7*1Cpromoter reporter gene was strongly activated by CAR, in contrast to the lack of activation of the CYP3A7 reporter (Fig.7 B). Mutation of only the ER6 motif in the CYP3A7 promoter to CYP3A4-ER6 was not, however, sufficient to achieve a significant increase in activation by CAR, whereas the reciprocal mutation in the CYP3A4 promoter ... WebMar 21, 2024 · CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Diseases associated with CYP3A7 include Myopathy, Centronuclear, 4 and Neonatal Abstinence Syndrome . Among its related pathways are Oxidation by … CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein … CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) is a Protein … ALOX5 (Arachidonate 5-Lipoxygenase) is a Protein Coding gene. Diseases … CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein … CYP4B1 (Cytochrome P450 Family 4 Subfamily B Member 1) is a Protein …
WebJan 30, 2024 · And we included another two CYP3A7 SNPs (rs2257401 and rs10211), the mutants of which might result in high expression of the CYP3A7 gene as CYP3A7*1C. rs2257401 is a missense mutation in the third exon of the CYPA7 gene , and the C to G mutation changes the amino acid residue from Thr to Arg in the translated protein. WebOct 24, 2024 · The allele frequency of CYP3A7*1C in Uyghur (0.019) was higher than that in Tibetan (0.002, p < 0.01). There was a strong linkage disequilibrium between CYP3A4 …
WebCYP3A7 is the predominant cytochrome P450 (CYP) expressed in human fetal liver, accounting for 30-50% of the total CYP in fetal liver and 87-100% of total fetal hepatic … Webnucleotide position -1105, and compared with those of the CYP3A7 gene, a fetal-specific form of cytochrome P450 in humans. The results showed that the identity of 5’-flanking sequences between CYP3A4 and CYP3A7 genes was 91 %, and that each 5’-flanking region had characteristic sequences
WebJul 13, 2024 · One locus within the CYP3A7 gene overlaps with our findings in males, but the other locus, mapping to MCM8, was specific to females. However, a majority (n = 8) of the male loci, was at least nominally significant in females, although the estimated effect sizes were lower. These results suggest that genetic effects on estradiol levels might ...
WebCYP3A4, CYP3A5, and CYP3A7, which are located in a multigene locus (CYP3A), play crucial roles in drug metabolism. To understand the highly variable hepatic expression of CYP3As, regulatory network analyses have focused on transcription factors (TFs). Since long non-coding RNAs (lncRNAs) likely contribute to such networks, we assessed the … dick smith 4gb mp3 playerWebMar 21, 2024 · Complete information for lnc-CYP3A7-2 gene (RNA Gene), , including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium dick smith 40inch tvWebOct 12, 2001 · A proximal promoter region from −1.0 kb to +105 of the CYP3A7gene also showed higher luciferase activity than did that of theCYP3A4 gene (Fig. 2). To identify a possible regulatory element(s) in the proximal promoter of the CYP3A7 gene, the sequences of the CYP3A7 and CYP3A4 genes were successively deleted as shown in … dick smith 427 cobraWebcontaining the complete CYP3A4 and CYP3A7 gene sequences, in-cluding 5 - and 3 -flanking sequence (Fig. 1A), was identified. The BAC clone was purified by using a maxiprep kit (QIAGEN, Valencia, dick smith abnWebSep 1, 2005 · Due to a replacement of part of the CYP3A7 promoter with a sequence identical with the same region in the CYP3A4 promoter (referred to as CYP3A7*1C), some individuals still express a variant of the CYP3A7 gene later in life. Objective: The objective of this study was to examine the effect of the CYP3A7*1C polymorphism on serum … citrus heights salary scheduleWebNov 18, 2002 · Mutations in CYP3A7 5′-flanking, coding and intronic domains. The identification of SNPs in the CYP3A7 gene has lagged somewhat behind research on CYP3A4 and CYP3A5. Compared to the wild-type sequence (CYP3A7*1A [106]), Kuehl et al. [17] identified four unique mutations in the CYP3A7 5′-flanking region. citrus heights salary tableWebJun 1, 2007 · To determine the frequencies and haplotypes of the cytochrome P450 (CYP)3A7 gene in three Chinese ethnic groups, namely, Han, She and Dong. SNP analyses of the CYP3A7 gene were carried out on ... dick smith ac