Folate hydrolase
WebMar 21, 2024 · folate hydrolase,prostate-specific membrane antigen identified by a monoclonal antibody (7E11-C5.3) expressed by normal,neoplastic,metastatic,prostatic … WebNov 28, 2024 · Backgrounds Folate Hydrolase‐1 (FOLH1; PSMA) is a type II transmembrane protein, luminally expressed by solid tumour neo‐vasculature. Monoclonal antibody (mAb), J591, is a vehicle for mAb ...
Folate hydrolase
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WebAug 14, 2007 · In this issue of Structure, Amzel, Bessman, and colleagues (Gabelli et al., 2007) present the crystal structure of a 17 kDa Nudix hydrolase from Escherichia coli previously characterized as a dATPase and provide evidence that it functions in vivo to remove pyrophosphate from the folate precursor dihydroneopterin triphosphate. WebNov 30, 2016 · The B-vitamin folate plays an established protective role in the prevention of neural tube defects (NTD) [1,2].This discovery led to the introduction of worldwide recommendations for women planning a pregnancy to take folic acid (FA) supplements from before conception and up to the 12th gestational week in order to ensure optimal …
WebAbstract. Human Prostate Specific Membrane Antigen (PSMA), also known as folate hydrolase I (FOLH1), is a 750-amino acid type II membrane glycoprotein, which is … Webγ-Glutamyl hydrolase (GGH, EC 3.4.19.9) catalyzes removal of the polyglutamyl tail from folyl and p-aminobenzoyl polyglutamates. Plants typically have one or a few GGH genes; Arabidopsis has three, tandemly …
WebOct 30, 2008 · Abstract. Increased expression of PSMA, a differentiation antigen with folate hydrolase activity, is an independent marker of prostate cancer progression. Mice expressing moderate levels of human PSMA in their prostate develop PIN-like lesions by 9 months. The aim of this study was to determine whether PSMA is involved in prostate … Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa.
WebSep 1, 1996 · Abstract. A novel monoclonal antibody has been developed that reacts strongly with human prostatic cancer, especially tumors of high grade. This antibody (7E11C-5) is currently in Phase 3 trials as an imaging agent for metastatic disease. We have cloned the gene that encodes the antigen that is recognized by the 7E11C-5 monoclonal …
WebJan 2, 2024 · Abstract. Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely … jessica m hess san diego caWebMar 29, 2024 · FOLH1 folate hydrolase 1 [ Homo sapiens (human) ] Gene ID: 2346, updated on 21-Mar-2024 Download Datasets Summary Official Symbol FOLH1 provided … jessica meyers ddsWebAug 24, 2012 · The folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates folate absorption by cleaving glutamates from dietary polyglutamyl folates. FOLH1is on chromosome 11p11.2 in human. A variant in this gene may be associated with impaired intestinal absorption of dietary folate. jessica meyers lawyerWebGCPII has been recognized as a neuropeptidase in the central nervous system, as a folate hydrolase participating in absorption of folates in the jejunum and, most importantly, as … jessica michele hannaWebOct 1, 1996 · We have identified that PSM antigen is a pteroyl poly-gamma-glutamyl carboxypeptidase (folate hydrolase) and is expressed strongly in human prostate cancer. Cancer cells that express this enzyme... inspections in health and social careWebNov 27, 2007 · Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCP2) gene. jessica meyers floridaWebPinto JT, Suffoletto BP, Berzin TM, et al. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res. 1996; 2:1445–1451. [Google Scholar] 11. Carter RE, Feldman AR, Coyle JT. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a ... inspections in carlisle pa