WebNov 23, 2024 · GLUT2 is a facilitative, bidirectional transporter. It passively transports intracellular glucose and galactose across the basolateral membrane of cells including … WebMar 16, 2024 · Objective: Glucose transporter 2 (GLUT2) is expressed in the pancreatic β-cell, intestine, liver, and kidney in mice. Although GLUT2 is considered as a major regulator of insulin secretion, in vivo contribution of β-cell Glut2 to glucose-stimulated insulin secretion and systemic glucose homeostasis is undefined. Therefore, the main objective of this …
GLUT2 - an overview ScienceDirect Topics
WebObjective: Glucose transporter 2 (GLUT2) is expressed in the pancreatic β-cell, intestine, liver, and kidney in mice. Although GLUT2 is considered as a major regulator of insulin secretion, in vivo contribution of β-cell Glut2 to glucose-stimulated insulin secretion and systemic glucose homeostasis is undefined. Therefore, the main objective of this study is … WebEl GLUT2 es un transportador de glucosa con baja afinidad, se expresa en el hígado, riñón, células β del páncreas y en la membrana basolateral de las células epitelia- les del intestino delgado,7 El GLUT2 participa en la regulación de la secreción de insulina: sólo permite el transporte de glucosa cuando la concentración plasmática ... post office sutton valence
In pancreatic islets from type 2 diabetes patients, the dampened ...
WebAug 1, 2002 · Glut2 mRNA levels were analyzed in total RNA samples from whole pancreas. Because Glut2 expression is limited to β-cells, the dilution by exocrine cell mRNA did not affect the analysis. No significant differences were observed in Glut2 mRNA level or protein expression between control and Foxa2 loxP/loxP;Ins.Cre islets (Fig. 3A–C). WebMay 25, 2024 · To ascertain the function of GLUT2 in glucose uptake in human β cells, we used a GLUT2 inhibitor, fisetin 45, to block GLUT2 function in the hPSC-derived pancreatic β-like cells. We treated the β-like cells with increasing dosages of 0, 30, 60, 90 and 120 μM fisetin to determine the specificity of the GLUT2 inhibitor (Figs. S10a and S10b ). WebOct 1, 2005 · These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control. Diabetes management is directed toward control of postprandial fluctuations or excursions in blood glucose, which reflect the relative rates of ... post office suwanee