Nettet22. mar. 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, … Nettetbeta-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar phenotype with beta-Klotho-deficient mice. FGF-15 secretion by the intestine regulates hepatic bile acid biosynthesis.
Toward a Better Understanding of Klotho - Science
NettetKlotho acts as a cofactor for interaction of FGF-23 with FGF R1 (6). This interaction negatively regulates 1 alpha -hydroxylase, the rate-limiting enzyme in the synthesis of … Nettet8. aug. 2024 · Researchers discovered the klotho protein in 1997, when they found that diminished levels seemed to make the animals age faster. Conversely, mice genetically engineered to maintain elevated... children\u0027s toy chest white
β-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile …
Nettet9. nov. 2024 · Klotho depletion in the CP caused by aging or experimental manipulation. (A) CP (arrow) in the lateral ventricle of a 4-mo-old WT mouse visualized by klotho immunostaining of a coronal brain section.(B) Images of confocal optical sections of CPs in the lateral ventricles of 4-mo-old WT and kl/kl mice immunostained for klotho (green) … NettetThe Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. … The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, and klotho protein has been shown to be a circulating factor detectable in serum that declines with age. Se mer Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. … Se mer The α-klotho gene is located on chromosome 13, and is translated into a single-pass integral membrane protein. The intracellular portion of the α-klotho protein is short (11 Se mer α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is … Se mer • Shimoyama Y, Taki K, Mitsuda Y, Tsuruta Y, Hamajima N, Niwa T (2009). "KLOTHO gene polymorphisms G-395A and C1818T are associated with … Se mer Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in ageing. … Se mer Reduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet. Se mer • Biology portal • "KL klotho [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-03-20. Se mer go with the flow of life quotes