WebAug 28, 2015 · This stimulation can also be mimicked by mitogen phorbol 12-myristate 13-acetate (PMA) and ionomycin (Ion), which is another similarity between naive and Jurkat T cells [17,18].Using different stimulation time points offers a way to analyze the toxic effects of TCE and its oxidative metabolites, TCA and DCA, on the dynamic process of activation ... Webmyristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells[3][7]. IC₅₀ & Target PKC 11.7 nM (EC50) NF-κB In Vitro In order to examine the role of PKC in p38MAPK phosphorylation, the cells are stimulated with the PKC activator, PMA (100
SAFETY DATA SHEET - Fisher Sci
WebEach vial of this cocktail contains phorbol-12-myristate 13-acetate (40.5 µM), ionomycin (669.3 µM), and Brefeldin A (2.5 mg/ml) in DMSO (500X). Storage & Handling Store cocktail at -70°C upon receipt. Protect from light. Avoid repeat freeze/thaw cycles. Application Activ, FC, ICFC - Quality tested Recommended Usage WebPhorbol 12-myristate 13-acetate C36H56O8 CID 27924 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, … can i download figma files
Pma (phorbol 12-myristate 13-acetate) Sigma-Aldrich
WebPerinatal infections have a negative impact on brain development. However, the underlying mechanisms leading to neurological impairment are not completely understood and … WebThe human monocytic cell line, THP-1, is the most widely used model for primary human monocytes/macrophages. This is because, following differentiation using phorbol 12-myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which mimics, in many respects, primary human macropha … WebMar 14, 2024 · THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA) are widely used as a model for function and biology of human macrophages. However, the conditions used for differentiation,... fit subscription box