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Top2a

Web14. dec 2011 · Interacts with HNRNPU (via C-terminus); this interaction protects the topoisomerase TOP2A from degradation and positively regulates the relaxation of supercoiled DNA in a RNA-dependent manner (By similarity). Interacts with MCM3AP (By similarity). Interacts with ERCC6 (By similarity). Interacts with PLSCR1 (By similarity). Web2. jún 2024 · Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for establishing mitotic chromosome condensation. The primary roles of …

Study on the expression of TOP2A in hepatocellular carcinoma …

WebTOP2A overexpression significantly correlates with more advanced AJCC stages and independently predicts worse DSS and DMFS. TOP2A is highly overexpressed in … WebThis antibody detects endogenous levels of Human TOP2A (Phospho Ser1213) Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Source: Rabbit: Dilution: WB 1:1000-2000 ELISA 1:5000-20000: Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. examples of poverty in a raisin in the sun https://lerestomedieval.com

TOP2A 靶点蛋白 抗体药物 临床药物信息 - ACROBiosystems中国

Web4. jún 2013 · Therefore, our study was designed to target TOP1, TOP2A and TOP2B genes in 105 fresh-frozen diagnostic biopsies by allelotyping and real-time quantitative PCR. Our analyses in those pediatric osteosarcomas, homogeneously treated, highlighted the frequent involvement of topo-isomerase genes. The main and most important observation was the ... http://www.biodragon.cn/cgkt/110956.html Web24. okt 2024 · MF4：在靶向治疗的三个时间节点上无明显规律，该cluster表达了增殖的髓系细胞基因(TOP2A, MKI67)。 T/NK细胞(n = 2,226)进一步聚类，细分成5个亚群并，进行marker基因的注释(图C-D)。 在RD肿瘤中，T细胞总体比例较高(图4C)，且没有单个T细胞亚簇在RD中富集。 bryan fitzpatrick captrust

ARID1A regulates R-loop associated DNA replication stress

Category:Nat Med：化疗药物阿霉素导致心力衰竭机制被揭开-MedSci.cn

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Top2a

Topoisomerase IIα is essential for maintenance of mitotic

Web5. sep 2024 · 参考文献 Top2A是一种编码拓扑异物酶 的编码基因，位 于 l7号染色体 ，是蒽环类药物的作用靶点。近年来 ，大 量文献报道 ，Top2A与 Her．2基因共表达 ，由此推测 ， Top2A与 Her一2共表达的患者可以从蒽环类化疗 中获 益 ，而 Her一2阴性患者则相反。 Web28. feb 2024 · TOP2A and TOP2B, which efficiently remove Sc +, have been reported in mitochondria of human cells, and in bovine mitochondria and mouse brain and sperm …

Top2a

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DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products o… Webtop2a是蒽环类药物的作用靶点，近年的研究普遍认为top2a与her-2基因共表达的患者可以从蒽环类化疗中获益 ，hertel等 的研究表明her-2阴性但top2a高表达的患者，使用蒽环类药物同样可以从临床治疗中获益。

Web2. feb 2024 · Topo IIα Antibody (F-12) is an IgG 1 κ mouse monoclonal Topo II alpha antibody (also designated TOP2A antibody, Topoisomerase IIα antibody or DNA Topoisomerase II alpha antibody) suitable for the detection of the Topo II alpha protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Topo IIα Antibody (F-12) is … Web29. jún 2024 · 在pca后，会发现pc8与pc10中包括top2a和mki67的细胞周期mark。可以尝试数据中回归该信号，避免影响下游分析。 三、获取细胞周期分数. 首先，我们根据每个细胞的g2 / m和s期标志物的表达为其分配分数。

Web28. dec 2024 · The sequence of 1 of the TOP2A cDNAs is identical to that of an internal fragment of the TOP2 cDNA isolated by Tsai-Pflugfelder et al. (1988). Southern blot analysis indicated that the TOP2A and TOP2B cDNAs are derived from distinct genes. Northern blot analysis using a TOP2A-specific probe detected a 6.5-kb transcript in the human cell line … Web1. júl 2024 · Topoisomerase IIα (TOP2A) plays an oncogenic role in multiple tumor types. However, no pan-cancer analysis about the function and the upstream molecular …

Web6. okt 2024 · TOP2A encodes DNA topoisomerase II alpha, an enzyme that controls and alters the topologic states of DNA, involves in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress during DNA transcription and replication. TOP2A was frequently identified as a top overexpressed …

Web26. mar 2024 · 图5展示了与细胞增殖相关的基因，如MKI67和TOP2A在cluster 5中高表达，提示cluster 5作为CD8 + Naïve T细胞终末分化状态是一种增殖型细胞（Proliferating）。除此之外，如果有特别关注的基因也可以基于关注的基因进行绘制。 examples of power corruptionWeb进而，利用小分子化合物抑制 Bub1 的激酶活性后， TOP2A 在着丝粒的定位几乎消失（图 2B ），说明 Bub1 的激酶活性对于 TOP2A 的着丝粒定位是必需的。 图 2 ：敲减 Bub1 的表达（ A ）或利用小分子化合物抑制 Bub1 的激酶活性（ B ）去除 TOP2A 在有丝分裂前中期染色体 … examples of power and authorityWeb9. mar 2024 · Top2A expression is also down-regulated in secondary drug-resistant tumor populations and, in one case, was accompanied by genomic deletion of Top2A. these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIalpha by sumoylation and suppresses tumorigenesis. examples of powerapp formsWeb28. feb 2024 · TOP2A is a key enzyme for DNA repair, cell cycle regulation, and chromosome division. TOP2A is also a potential target for many anticancer drugs such as anthracyclines, and its expression level is also related to the efficacy of anthracyclines. Anthracyclines are used to treat a variety of cancers. bryan fitzpatrick new orleansWebTOP2A. 这个基因编码一种DNA拓扑异构酶，这种酶在转录过程中控制和改变DNA的拓扑状态。. 这种核酶参与诸如染色体凝聚、染色单体分离以及DNA转录和复制过程中发生的扭转 … examples of povertyWeb21. mar 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … bryan fitzpatrick lawyer bcWebMonoclonal Antibody for studying TOP2A. Validated for WB, IHC, IF, F. Highly specific and rigorously validated in-house, Topoisomerase IIα (D10G9) XP® Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #27498) is ready to ship. examples of poverty in uk